Complications Associated With The Treatment Of Chlamydial Infections
The primary frontline antichlamydial antibiotics, tetracyclines and azithromycin , are highly effective in the treatment of uncomplicated chlamydial infections . However, accumulating data suggest that a break in the normal chlamydial developmental cycle can result in persistence and long-term infection that is refractory to antibiotic therapy. An understanding of this phenomenon is far from complete. Although 50% of genital C. trachomatis infections resolve spontaneously within 1 year of testing , a further understanding of long-term infections is important, because it is hypothesized that persistence can cause a cascade of potentially serious inflammatory-induced sequelae, such as pelvic inflammatory disease, infertility, blindness, arthritis, asthma and atherosclerosis .
Antibiotics For Chlamydia: Treatment
Antibiotics work very well to treat infections like Chlamydia and Gonorrhea. Unlike gonorrhea bacterium which is intra-cellular the Chlamydia bacterium is inter-cellular and live within the cell of the host. So the antibiotics have to kill the bacterium rather than merely destroy its cell walls. Some antibiotics do it with great potency and the infection is generally cured within 10 days.
Chlamydia Antibiotics like Doxycycline and Azithromycin are the preferred antibiotics. They have a very high cure rate of only a week in up to 98% of cases. Few cases might take longer to cure. It is also advised to complete the course of antibiotics even after the disease is cured within a week so as to eliminate any residual strains.
Penicillin was a very popular antibiotic used to treat STD-like Gonorrhea and Chlamydia. Over the years though the Chlamydia and Gonorrhea bacterium have mutated to exhibit resistance and immunity to penicillin. Due to that it is no longer the preferred antibiotic to treat chlamydia. Other medications like ofloxacin, erithromycin and Levofloxacin can be used but they carry increased risk of side effects. Moreover their cure rates are not as good as azithromycin and doxycycline.
Common Side Effects Of Chlamydia Antibiotics
Chlamydia is always treated by antibiotics. Popular antibiotics for chlamydia infection including Erythromycin, Levofloxacin, Tetracycline, Azithromycin, Doxycycline, and so on. A single dose of antibiotics is good to treat chlamydia infection in most cases.You will get a negative result of chlamydia test after the treatment. If you are sill suffering from chlamydia symptoms, or have got a positive result again, visit your doctor.
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How Chlamydia’s Passed On
Chlamydia is usually passed from one person to another through sexual contact.
You can get the infection if you come into contact with the semen or vaginal fluids of someone who has chlamydia.
Chlamydia is most commonly spread through:
- vaginal or anal sex without a condom
- sharing sex toys that arent washed or covered with a new condom each time theyre used.
It can be spread by giving or receiving oral sex with someone who has chlamydia. The risk can be lowered by using a condom or a dam to cover the genitals.
If infected semen or vaginal fluid comes into contact with the eye it can cause conjunctivitis (infection or irritation of the eye.
If youre pregnant its possible to pass chlamydia to the baby .
Its not clear if chlamydia can be spread by transferring infected semen or vaginal fluid to another persons genitals on the fingers or through rubbing vulvas together.
You cant get chlamydia from kissing, hugging, sharing baths or towels, swimming pools, toilet seats or from sharing cups, plates or cutlery.
When Will The Signs And Symptoms Go Away
You should notice an improvement quite quickly after having treatment.
- Discharge or pain when you urinate should improve within a week.
- Bleeding between periods or heavier periods should improve by your next period.
- Pelvic pain and pain in the testicles should start to improve quickly but may take up to two weeks to go away.
If you have pelvic pain or painful sex that doesnt improve, see your doctor or nurse as it may be necessary to have some further treatment or investigate other possible causes of the pain.
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Endpoints For Monitoring Therapy
It is generally considered that tests of cure are not required for evaluating treatments for chlamydial infection. With adequate compliance, cure rates in the upper 90 percentile range are expected. Using single doses of oral azithromycin may remove the compliance concern. Where there may be an indication that tests of cure are important, there are certain caveats that must be considered. With some antibiotic regimens it is possible to suppress chlamydiae and render early tests of cure inaccurate. Thus, it is inappropriate to perform a test of cure one week after treatment has been completed. It is more prudent to wait at least three weeks after treatment to assess potential failures. This, of course, introduces a problem of potential re-infection. That potential is most marked in sexually transmitted infections where re-exposure to untreated partners or infected others within the same group may result in a positive test as a result of reinfection rather than treatment failure.
Diagnosis And Treatment Of Chlamydia Trachomatis Infection
KARL E. MILLER, M.D., University of Tennessee College of Medicine, Chattanooga, Tennessee
Am Fam Physician. 2006 Apr 15 73:1411-1416.
Chlamydia trachomatis infection most commonly affects the urogenital tract. In men, the infection usually is symptomatic, with dysuria and a discharge from the penis. Untreated chlamydial infection in men can spread to the epididymis. Most women with chlamydial infection have minimal or no symptoms, but some develop pelvic inflammatory disease. Chlamydial infection in newborns can cause ophthalmia neonatorum. Chlamydial pneumonia can occur at one to three months of age, manifesting as a protracted onset of staccato cough, usually without wheezing or fever. Treatment options for uncomplicated urogenital infections include a single 1-g dose of azithromycin orally, or doxycycline at a dosage of 100 mg orally twice per day for seven days. The recommended treatment during pregnancy is erythromycin base or amoxicillin. The Centers for Disease Control and Prevention and the U.S. Preventive Services Task Force recommend screening for chlamydial infection in women at increased risk of infection and in all women younger than 25 years.
SORT: KEY RECOMMENDATIONS FOR PRACTICE
Azithromycin or doxycycline is recommended for the treatment of uncomplicated genitourinary chlamydial infection.
SORT: KEY RECOMMENDATIONS FOR PRACTICE
Azithromycin or doxycycline is recommended for the treatment of uncomplicated genitourinary chlamydial infection.
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How Long Does It Take For Chlamydia To Go Away After Treatment
Chlamydia infection usually clears after one week of completing your antibiotic treatment. During treatment, you should avoid drinking alcohol as this can reduce how effective the antibiotic is.
You should also avoid having sex during treatment as you could still pass on the infection to your partner. It is common for partners to pass chlamydia between one another if they continue to have sex without completing their treatment, causing repeated infections.
Treatment For Chlamydia Is Quick And Easy
Two antibiotics are most often used for treating chlamydia:
- Azithromycin The main treatment for chlamydia is one gram of azithromycin, taken one time, says , deputy director of clinical services for public health with the Seattle and King County HIV and STD Program in Washington. That one gram comes as either two pills or four pills. It is not expensive.
- Doxycycline If your doctor prescribes doxycycline, you will take two pills daily for one week. It costs somewhat more than azithromycin.
Antibiotics can also cure chlamydia in infants, who can get the infection from their mothers, and treatment is essential for them. Without treatment, infants infected with chlamydia can develop conjunctivitis, which can cause blindness, or pneumonia, which can be fatal.
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Treatment Of Other Types
Two other conditions caused by Chlamydia trachomatis are uncommon in the United States, but very common worldwide:
- Lymphogranuloma venereum : Lymphogranuloma venereum is treated in the same way as standard genital chlamydia infections, but a longer course of therapy is used . Other care may also be required to treat genital ulcers or abscessed inguinal nodes if they occur.
- Trachoma: Trachoma is the leading preventable cause of blindness worldwide and often requires aggressive treatment with antibiotics and surgery addressing unsanitary living conditions is also necessary.
The Best Antibiotics For Chlamydia: First
Chlamydia can be easily treated and cured with antibiotics. However, not all antibiotics are effective.
The Centers for Disease Control and Prevention recommends doxycycline or azithromycin as first-choice antibiotic for the treatment of genital chlamydia. These medications are very effective for both acute and persistent infections.
Important note: To avoid reinfection, persons with chlamydia should abstain from sexual activity until they and their sex partners have completed the treatment.
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What Happens If Chlamydia Is Left Untreated
If left untreated, chlamydia can lead to more serious health problems.
In people assigned female at birth, untreated chlamydia can cause pelvic inflammatory disease , a condition which can scar the fallopian tubes and lead to infertility.
Chlamydia can also be passed on to babies during birth if the parent has the infection while pregnant.
Male Complications Of Untreated Chlamydia
These are just some of the most common complications of untreated chlamydia, which is why its important to get medical attention right away. Most people who get treatment quickly have no long-term medical problems.
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For Which Stds Are Antibiotics Taken
Antibiotics are effective only against diseases caused by bacteria gonorrhea, syphilis, chlamydia, trichomoniasis, venereal lymphogranulomatosis, AIDS. However, they are powerless against viruses, fungi or parasites.
The complexity of the selection of therapy lies in the difficulty of determining the pathogen. The occurrence of some sexually transmitted diseases, for example, Reiters disease, is associated with past infections gonorrhea and chlamydia, but scientists have not yet been able to unequivocally determine whether they belong to a certain type.
What Are Oral Chlamydia Symptoms
Like most STDs, partners exposed to chlamydia may exhibit no symptoms. Similarly, in oral chlamydia, most people have no symptoms. When symptoms arise, some experience a sore throat. While others, may experience redness of the throat. In any situation, if you or a partner have been exposed to someone who has chlamydia, it is best to get treated as soon as possible to avoid complications.
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Chlamydial Infection Among Adolescents And Adults
Chlamydial infection is the most frequently reported bacterial infectious disease in the United States, and prevalence is highest among persons aged 24 years . Multiple sequelae can result from C. trachomatis infection among women, the most serious of which include PID, ectopic pregnancy, and infertility. Certain women who receive a diagnosis of uncomplicated cervical infection already have subclinical upper genital tract infection.
Asymptomatic infection is common among both men and women. To detect chlamydial infection, health care providers frequently rely on screening tests. Annual screening of all sexually active women aged < 25 years is recommended, as is screening of older women at increased risk for infection . In a community-based cohort of female college students, incident chlamydial infection was also associated with BV and high-risk HPV infection . Although chlamydia incidence might be higher among certain women aged 25 years in certain communities, overall, the largest proportion of infection is among women aged < 25 years .
Effects Of Chlamydia Treatment
After you have begun your course of chlamydia treatment, you should start to notice an improvement in your symptoms within a few days. Generally, most symptoms should resolve completely within 24 weeks. If any symptoms persist, such as pelvic pain or pain during sex, please return to the clinic as further treatment or investigations may be necessary.
If you are diagnosed with chlamydia you may need to inform anyone you have had sex with within the last six months as they may also be infected. They should be advised to attend a sexual health clinic for a chlamydia test and will usually be offered treatment on the day they attend. This advice is regardless of whether they have any symptoms or not, or whether or not you used a condom.
If you feel unable to inform previous sexual partners one of our Health Advisers will be able to notify them on your behalf without revealing your identity.
You should not have oral, anal or vaginal sex during your course of chlamydia treatment or for seven days after a single dose of chlamydia treatment and also until your current partner completes their treatment and until both you and your partners symptoms have abated. This is to avoid being re-infected and requiring further treatment.
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Put Sex On Hold During And After Chlamydia Treatment
If you were given a single dose of antibiotics to treat your chlamydia, you should not have any kind of sex for a full seven days after the day you took the medicine. If youre taking antibiotics for a week, wait another seven days after the last day of your treatment. Be sure to take all of the medicine that is prescribed for you.
Not having sex for seven days after treatment is important so you dont spread the infection to your partner or partners.
Medication stops the infection and can keep you from spreading the disease, but it wont cure any permanent damage that the infection caused before you started treatment. In women, such damage can include blocking the fallopian tubes, causing infertility.
If you still have symptoms for more than a few days after you stop taking your medicine, go back to see your doctor or other healthcare provider so they can check you again.
Treatment Adherence And Safety
In the azithromycin group, two participants vomited azithromycin within 1 hour after taking it, and a second dose was administered successfully. In the doxycycline group, 77% of participants received 14 doses because of the logistic challenges inherent in conducting the study in youth correctional facilities, 2% of participants received 11 doses, 3% received 12 doses, 12% received 13 doses, 6% received 15 doses, and 1% received 16 doses. No participants were excluded from the per-protocol population because they received an insufficient number of doxycycline doses. Adverse events were reported by 23% of the participants in the azithromycin group and by 27% of the participants in the doxycycline group the most common adverse events reported in both groups were gastrointestinal symptoms. No severe or serious adverse events occurred, and no participants discontinued participation in the study because of an adverse event.
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Management Of Sex Partners
Sex partners should be referred for evaluation, testing, and presumptive treatment if they had sexual contact with the partner during the 60 days preceding the patients onset of symptoms or chlamydia diagnosis. Although the exposure intervals defining identification of sex partners at risk are based on limited data, the most recent sex partner should be evaluated and treated, even if the time of the last sexual contact was > 60 days before symptom onset or diagnosis.
Randomization And Sequence Generation Allocation Concealment And Blinding
A computer-generated randomization sequence will be created by an independent statistician. Blinded therapy will be prepared by an independent organization and labelled with individual kit numbers according to randomization. Study drugs will be packaged into individually numbered kits stored by independent site pharmacists. All tablets will be identical in appearance and feel, and all medications will be packaged identically to maintain blinding. Participants, physicians, nurses, trial statistician and all other trial staff will be masked to treatment group. The effectiveness of blinding will be tested at completion of the trial when participants will be asked to indicate which treatment they thought they received .
The side-effect profiles of the drugs will have negligible impact on blinding. They have been widely used for chlamydia for decades at the dosages we will be using. Their side-effect profiles are well established and similar including minor gastrointestinal upset . Photosensitivity may occur for doxycycline but is more common with longer or higher dosages . Rash is a rare side effect for each drug, occurring in 0.11% of cases . Our packaging will clearly state sunscreen should be used and exposure to sun minimalized, thereby reducing the risk of photosensitivity. We examined the side-effect data from treatment trials for urethral/cervical chlamydia and found that among 17 trials, there was no difference in side-effects .
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Testing And Treating Sexual Partners
If you test positive for chlamydia, it’s important that your current sexual partner and any other recent sexual partners you’ve had are also tested and treated.
A specialist sexual health adviser can help you contact your recent sexual partners, or the clinic can contact them for you if you prefer.
Either you or someone from the clinic can speak to them, or the clinic can send them a note to let them know they may have been exposed to a sexually transmitted infection .
The note will suggest that they go for a check-up. It will not have your name on it, so your confidentiality will be protected.
Page last reviewed: 01 September 2021 Next review due: 01 September 2024
Azithromycin Safe Effective Treatment For Chlamydia
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The efficacy of azithromycin was similar, though not noninferior, to doxycycline for the treatment of urogenital Chlamydia trachomatis infection, according to recent data.
During a recent investigation, 97% of patients who received azithromycin were cured of chlamydia, according to William M. Geisler, MD, professor in the division of infectious diseases at the University of Alabama at Birmingham, and colleagues. Geisler, a co-author of CDCs chlamydia guidelines, said in a press release that the drug should be considered as a front-line therapy.
William M. Geisler
Recent studies have raised concerns over the efficacy of azithromycin, and there has not been a definitive, well-controlled randomized clinical trial of its effectiveness, Geislersaid in the release. For physicians, knowing whether azithromycin is an effective treatment option is important because patient adherence to therapy with doxycycline can be an issue. Azithromycin requires only one dose, while doxycycline requires patients to take multiple pills over 7 days.
Fifty-five percent of participants in each arm of the study completed the first follow-up. No treatment failures were reported in the doxycycline arm however, five asymptomatic patients in the azithromycin arm tested positive for chlamydia at follow-up . The failure rate differed by 3.2% between the groups .
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