Doxycycline Resistance And C Trachomatis
Despite the absence of recent MIC data for C. trachomatis, low values of MICs of doxycycline were reported in the literature with MIC90 usually0.125 mg/L.,, Interestingly, doxycycline minimum chlamydiacidal concentrations varied according to the clinical presentation and the bacterial serovar, with lower MCCs in cases of asymptomatic infection than in mucopurulent cervicitis and pelvic inflammatory disease, and the highest MCCs observed for serovar Ia and J in mucopurulent cervicitis and pelvic inflammatory disease. In contrast, no MIC or MCC difference was observed between isolates recovered in the case of treatment failure or persistence compared with single-episode isolates. From these data and treatment success rates, pathogen resistance is expected to be low. However, tetracycline- and doxycycline-resistant isolates and isolates resistant to multiple antibiotics have been reported, some of thembut not allbeing involved in relapsing or persistent infection.
Doxycycline Resistance And M Genitalium
Information on antimicrobial susceptibility of M. genitalium is scarce because of the limited number of strains isolated from clinical samples. Studies reporting MICs of doxycycline usually found low MIC values, i.e. 5 strains with MICs ranging from0.008 to 0.031 mg/L and 14 strains with MICs ranging from 0.06 to 0.12 mg/L . However, an in vitro antimicrobial susceptibility testing study conducted using both broth dilution and quantitative PCR showed an MIC range of 0.0631 mg/L indicating that the strains displayed reduced susceptibility to doxycycline but that these isolates remained rare. Finally, a recent larger study showed that 2 isolates out of 103 displayed MIC> 8 mg/L while for other isolates, MICs ranged from< 0.125 to 2 mg/L. However, doxycycline MICs did not correlate with treatment outcomes in this study. As far as molecular detection of mutations mediating resistance is concerned, macrolides and fluoroquinolones were mainly studied and to our knowledge, tetracycline resistance-associated mutations have not so far been identified in M. genitalium. Altogether, MICs mostly indicated susceptibility of M. genitalium to doxycycline and the rare isolates with reduced susceptibility cannot explain the poor efficacy of doxycycline in the treatment of M. genitalium infections., Considering the emergence of MDR M. genitalium strains, it thus appears important to elucidate reasons other than poor patient compliancefor the poor efficacy of doxycycline.
Testing And Treating Sexual Partners
If you test positive for chlamydia, it’s important that your current sexual partner and any other recent sexual partners you’ve had are also tested and treated.
A specialist sexual health adviser can help you contact your recent sexual partners, or the clinic can contact them for you if you prefer.
Either you or someone from the clinic can speak to them, or the clinic can send them a note to let them know they may have been exposed to a sexually transmitted infection .
The note will suggest that they go for a check-up. It will not have your name on it, so your confidentiality will be protected.
Page last reviewed: 01 September 2021 Next review due: 01 September 2024
Also Check: Azithromycin 500 Mg 2 Pills For Chlamydia
Amoxicillin For Chlamydia: Is It Effective
Amoxicillin is not the preferred treatment option for gonorrhea, but is it an effective way to treat chlamydia? The CDC reports that chlamydia can be easily treated with a course of antibiotics. But this does not mean that amoxicillin is effective simply because it is an antibiotic.
The CDC recommends that healthcare providers prescribe either azithromycin or doxycycline to treat chlamydia. The CDC also suggests several alternative antibiotics that can be used to treat chlamydia, including erythromycin, levofloxacin, or ofloxacin.
Amoxicillin is not on the list of antibiotics that the CDC recommends for the general treatment of chlamydia. However, it is on the list of antibiotics that the CDC recommends for the treatment of chlamydia in pregnant women. So if you are pregnant, your doctor may prescribe amoxicillin to treat chlamydia.
Doxycycline Resistance And T Pallidum
Although serological failure, defined as a lack of 4-fold decline in rapid plasma reagin titres following therapy, was observed in patients treated with doxycycline , no resistance study that could explain treatment failure was conducted and currently a unique study concerns doxycycline resistance of T. pallidum. In this study, Xiao et al. investigated the presence of the G1058C point mutation in the 16S rRNA gene associated with decreased susceptibility to doxycycline and found no mutation among 2253 whole blood specimens sampled from Chinese patients with secondary or latent syphilis between 2013 and 2015.
Don’t Miss: Is Itching A Symptom Of Chlamydia
What Do I Need To Know If I Get Treated For Gonorrhea
If youre getting treated for gonorrhea:
Take all of your medicine the way your doctor tells you to, even if your symptoms go away sooner. The infection stays in your body until you totally finish the antibiotics.
Your partner should also get treated for gonorrhea so you dont re-infect each other or anyone else.
Dont have sex for 7 days. If you only have 1 dose of medication, wait until a week after you take it to have sex. If youre taking medicine for 7 days, dont have sex until youve finished all of your pills.
Get tested again in 3 months to make sure your infection is gone.
Dont share your medicine with anyone. Your doctor may give you a separate dose of antibiotics for your partner. Make sure you both take all of the medicine you get.
If you still have symptoms after you finish your treatment, call your doctor.
Even if you finish your treatment and the gonorrhea is totally gone, its possible to get infected with gonorrhea again. Gonorrhea isnt a one-time-only deal. So use condoms and get tested regularly.
Is Treatment Different For Pregnant Women With Gonorrhea
Treatment is necessary to prevent disease transmission to, or complications for, the baby.
Gonorrhea in babies often manifests as conjunctivitis, or pink eye. Some states require that all newborns are given antibiotic eye drops, such as erythromycin, as a preventive measure against the disease.
Pregnant women who are diagnosed with gonorrhea should be tested for other STIs as well.
Read Also: Signs You May Have Chlamydia
Who Should Take An At
Before you start worrying about amoxicillin, you should first get a proper diagnosis. For cases in which chlamydia orgonorrhea symptoms are present, these are the signs to watch out for:
- More frequent urination or the urge to urinate
- Painful sensation when urinating
- Red and swollen penis near the urinary meatus
- Abnormal discharge or fluid from the penis or vaginal area
- Sore throat that wont go away
- Testicular pain and swelling in men
- Lower abdominal pain in women
- Heavier period or excessive spotting in women
If you notice any of these symptoms, its in your best interest to purchase an at-home STD kit to test for gonorrhea and chlamydia right away.
Dont assume that you dont need to get tested simply because you arent experiencing any symptoms. In many cases, gonorrhea and chlamydia may not show any visible signs of infection at all. For this reason, every sexually active person should be tested regularly for all common sexually transmitted infections.
In general, the CDC recommends that every sexually active adult get tested for chlamydia and gonorrhea at least once a year.But if you engage in certain sexual activities, you may need to get tested more frequently.This is especially true for people who meet one or more of the following conditions:
How Is Gonorrhea Treated
Gonorrhea doesn’t cause problems if it’s treated early. If not treated, it can lead to serious problems.
Gonorrhea is treated with antibiotics. Treatment is recommended for:
- A person who has a positive gonorrhea test.
- Anyone who has had sexual contact in the past 60 days with a person who’s been diagnosed with gonorrhea. Treatment is recommended even if you used condoms or if the other person doesn’t have symptoms.
- A newborn whose mother has gonorrhea at the time of delivery.
If you are prescribed more than one dose, be sure to take your antibiotic exactly as directed. If you miss doses or don’t take all of the medicine, the infection may not go away.
Do not have sexual contact with anyone:
- While you are being treated.
- Until both you and your partner have been tested and treated. If you are treated for gonorrhea and your sex partner is not, you will probably get infected again.
If your treatment is just one dose of medicine, wait at least 7 days after you take it before having any sexual contact.
Always use a condom when you have sex. This helps protect you from sexually transmitted infections.
Some people who have gonorrhea also have chlamydia. The U.S. Centers for Disease Control and Prevention recommends that treatment for gonorrhea include antibiotics that also treat chlamydia.
Treatment if the condition doesn’t get better
If your symptoms don’t go away, you may have another gonorrhea infection.
Perspectives Of Doxycycline Use In Stis
Recently, oral pre-exposure prophylaxis using a combination of the antiretroviral drugs tenofovir and emtricitabine has been recommended for preventing HIV infection among individuals at high risk, including MSM. In September 2015, the WHO recommended offering PrEP for all persons at substantial risk of HIV infection including MSM. A recent meta-analysis reported that MSM using PrEP were significantly more likely to acquire a N. gonorrhoeae, C. trachomatis or syphilis compared with MSM not using PrEP. Recreational drug use in MSM and the association with sexual risk behaviour have been documented on an international level and in Western Europe, where transmission of HIV and other STIs remains high. This partly explains why MSM are a high-risk STI group. These practices, called ChemSex are defined by the use of certain sexually-disinhibiting recreational drugs before or during sex with the specific purpose of facilitating or enhancing sex.
The questions about doxycycline in prophylaxis of bacterial STIs concern the safety and the risk for acquired resistance. Use of doxycycline in clinical practice to prevent STI, particularly C. trachomatis and syphilis, is still not validated, pending further analysis.
How Do Medications Treat Chlamydia
The medications used to treat chlamydia are antibiotics, which kill the bacteria that cause the infection. Generally, these medications are taken by mouth for one or seven days. Drugs to treat chlamydia may include azithromycin, doxycycline, or levofloxacin. Pregnant women with chlamydia should only take azithromycin, as other medications may harm the developing baby. Since chlamydia and gonorrhea often occur together, doctors may also treat people with chlamydia with ceftriaxone, a drug that treats gonorrhea.
Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.
Recommended Reading: Can You Be Exposed To Chlamydia And Not Get It
What Other Information Should I Know
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body’s response to ceftriaxone injection.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking ceftriaxone injection.
If you are diabetic and test your urine for sugar, use Clinistix or TesTape to test your urine while taking this medication.
Ceftriaxone injection may interfere with certain home blood glucose tests. If you test your blood glucose levels, check the instructions of your blood glucose monitoring system to see if ceftriaxone injection will affect your system. You may need to use a different method to test your glucose levels while you are receiving ceftriaxone injection.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Variability Of Doxycycline Pharmacokinetics
There are no data on the impact of gender, pregnancy, lactation or liver impairment on doxycycline pharmacokinetics.
The pharmacokinetics of doxycycline has been studied in the elderly, undernourished patients and patients with hyperlipidaemia, infected patients and patients with renal impairment.
In older patients , serum concentrations were higher than those reported for other age groups with a Cmax of 830 mg/L and concentrations at 10 h in the range 510 mg/L.
In undernourished patients, a decrease in the AUC is observed and, in patients with hyperlipidaemia, a significant increase in the AUC is observed.
Also Check: Side Effects To Chlamydia Medication
Frequently Asked Questionsexpand All
- What is a sexually transmitted infection ?
A sexually transmitted infection is an infection spread by sexual contact. There are many STIs. This FAQ focuses on chlamydia, gonorrhea, and syphilis. These STIs can cause long-term health problems and problems during pregnancy. Having an STI also increases the risk of getting human immunodeficiency virus if you are exposed to it.
- What is chlamydia?
Chlamydia is the most commonly reported STI in the United States. Chlamydia is caused by a type of bacteria, which can be passed from person to person during vaginal sex, oral sex, or anal sex. Infections can occur in the mouth, reproductive organs, urethra, and rectum. In women, the most common place for infection is the cervix .
- What are the risk factors for chlamydia?
The following factors increase the risk of getting chlamydia:
Having a new sex partner
Having more than one sex partner
Having a sex partner who has more than one sex partner
Having sex with someone who has an STI
Having an STI now or in the past
Not using condoms consistently when not in a mutually monogamous relationship
Exchanging sex for money or drugs
Chlamydia usually does not cause symptoms. When symptoms do occur, they may show up between a few days and several weeks after infection. They may be very mild and can be mistaken for a urinary tract or vaginal infection. The most common symptoms in women include
yellow discharge from the vagina or urethra
yellow vaginal discharge
Treatment For Chlamydia Is Quick And Easy
Two antibiotics are most often used for treating chlamydia:
- Azithromycin The main treatment for chlamydia is one gram of azithromycin, taken one time, says , deputy director of clinical services for public health with the Seattle and King County HIV and STD Program in Washington. That one gram comes as either two pills or four pills. It is not expensive.
- Doxycycline If your doctor prescribes doxycycline, you will take two pills daily for one week. It costs somewhat more than azithromycin.
Antibiotics can also cure chlamydia in infants, who can get the infection from their mothers, and treatment is essential for them. Without treatment, infants infected with chlamydia can develop conjunctivitis, which can cause blindness, or pneumonia, which can be fatal.
Recommended Reading: Does Chlamydia Make You Poop A Lot
Preventing The Spread Of Gonorrhea
To minimize the risk of transmitting gonorrhea to others, avoid having sexual intercourse for at least seven days after completion of treatment. Also encourage any sexual partners from within the past 60 days to see their own doctors for evaluation.
If a person diagnosed with gonorrhea is in a romantic relationship, their partner should also get tested for gonorrhea. Its still possible to contract gonorrhea while being treated for gonorrhea.
If both partners are diagnosed with gonorrhea, their treatment will be the same. Both will need to abstain from sexual intercourse until theyve completed treatment and are cured.
Chlamydia Treatment And Prevention
Chlamydia is easy to cure. If you test positive for chlamydia, basically you take an antibiotic, says Jill Rabin, MD, cochief in the division of ambulatory care for women’s health programs and prenatal care assistance program services for Northwell Health in New Hyde Park, New York.
Your partner must take an antibiotic, too, to keep them from reinfecting you, she says.
You have to have your partner treated, and if you have more than one partner, they should all be treated, says Dr. Rabin, regardless of your partners genders.
Even if you dont have chlamydia now, its wise to learn how to protect yourself so you wont develop this common infection in the first place. In women, chlamydia can create serious health problems, including infertility. Besides, no one ever wants to have a sexually transmitted disease and then have to tell other people about it.
Don’t Miss: Does Chlamydia And Gonorrhea Go Away
Parents Have A Role In Chlamydia Prevention
Parents can do two main things to help their kids avoid getting chlamydia and other sexually transmitted infections , says Dombrowski. These two things are:
When Should You Test For Gonorrhea Or Chlamydia At Home
If youve recently had unprotected sex or potentially been exposed to gonorrhea or chlamydia, you may think that its important to get tested immediately. But taking an STD test too soon could actually lead to inaccurate results. Why? STDs such as gonorrhea and chlamydia will not be detectable in your system immediately following exposure. If you take a test too early, you may get a false negative result.
So how long should you wait to get tested for STDs? Every STD has a unique incubation period, which is the amount of time that it takes for the STD to be detectable in your system. The incubation period for chlamydia can range from 7 days to 21 days, whereas the incubation period for gonorrhea is up to 14 days.
Therefore, it is best to get tested for chlamydia and gonorrhea two to three weeks following the initial exposure. If you take a test within the first two to three weeks following exposure, its best to get tested again after several weeks to ensure your initial results were accurate.
Also Check: Is Trichomoniasis And Chlamydia The Same Thing