What Are The Cautions Associated With Doxycycline Use
Although Doxycycline capsules are commonly prescribed in the UK to treat symptoms of Chlamydia, it is still important to check if the medication is suitable for you. Doxycycline should not be used by people suffering with certain medical conditions or those taking certain medications.
Doxycycline may increase the risk of developing skins reactions due to the sunlight. This is known as photo sensitivity. You should protect your skin from sunlight even on a bright but cloudy day and not use sunbeds and avoid excessive exposure to sunlight or sunlamps to reduce the risk of photosensitive reactions.
For a full list of Side Effects please
Very common side effects of Doxycycline include:
- Diarrhoea, which should be reported if severe or prolonged
- Visual disturbances such as blurring of vision, which if it does occur please avoid driving or operating machinery
- Oesophageal and gastrointestinal reactions including: sore mouth, indigestion, and difficulty swallowing
- Nausea or vomiting
- Muscle and joint pain
Perspectives Of Doxycycline Use In Stis
Recently, oral pre-exposure prophylaxis using a combination of the antiretroviral drugs tenofovir and emtricitabine has been recommended for preventing HIV infection among individuals at high risk, including MSM. In September 2015, the WHO recommended offering PrEP for all persons at substantial risk of HIV infection including MSM. A recent meta-analysis reported that MSM using PrEP were significantly more likely to acquire a N. gonorrhoeae, C. trachomatis or syphilis compared with MSM not using PrEP. Recreational drug use in MSM and the association with sexual risk behaviour have been documented on an international level and in Western Europe, where transmission of HIV and other STIs remains high. This partly explains why MSM are a high-risk STI group. These practices, called ChemSex are defined by the use of certain sexually-disinhibiting recreational drugs before or during sex with the specific purpose of facilitating or enhancing sex.
The questions about doxycycline in prophylaxis of bacterial STIs concern the safety and the risk for acquired resistance. Use of doxycycline in clinical practice to prevent STI, particularly C. trachomatis and syphilis, is still not validated, pending further analysis.
Preventing The Spread Of Infection
It is absolutely necessary to inform the partner if you get a positive test for Chlamydia. The sooner the partner is told the more effective and simple the treatment can be. Make sure your partner gets tested and receives the treatment as well and abstain from the intercourse until the treatment of both you and the partner is finished.
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How And When To Take It
Your dose of doxycycline depends on why you are taking it.
The usual dose is 100mg to 200mg once or twice a day. If you’re taking doxycycline more than once a day, try to space your doses evenly throughout the day. If you take it twice a day, this could be first thing in the morning, and in the evening.
For preventing malaria, you’ll take 100mg once a day, usually in the morning. Start taking doxycycline 1 or 2 days before going to an area where there is malaria. Carry on for 4 weeks after leaving the area. Check with your doctor or pharmacist that doxycycline is the best medicine to prevent malaria in the country you are travelling to.
Do I Need To Take Doxycycline With Or After Food
Food does not affect the absorption of doxycycline and you can choose to take doxycycline on an empty stomach or after food. One of the possible side-effects of taking doxycycline is that it may make you feel slightly nauseas. If this is the case, you may find it helpful to take doxycycline after a meal.
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Can I Still Pass On Chlamydia During Treatment
Yes, you can still pass on chlamydia even if you are being treated this is because the treatment hasnt killed off enough of the bacteria to make you non-contagious.
Having sex we dont recommend that you have sex, even with a condom, until you finish your treatment. If your partner also has chlamydia, you shouldnt have sex until you have both finished the treatment. Otherwise, you risk catching/passing on the infection again.
All sexual contact including with a condom should be avoided during treatment.
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Will I Need To Go Back To The Clinic
If you take your antibiotics correctly, you may not need to return to the clinic.
However, you will be advised to go back for another chlamydia test if:
- you had sex before you and your partner finished treatment
- you forgot to take your medication or didn’t take it properly
- your symptoms don’t go away
- you’re pregnant
If you’re under 25 years of age, you should be offered a repeat test for chlamydia 3 to 6 months after finishing your treatment because you’re at a higher risk of catching it again.
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Is Chlamydia Different In Men And Women
Chlamydia can act quite differently in men and women, which can make it hard to spot. Also, many people dont have any visible symptoms or do not notice them.
Because chlamydia is so difficult to diagnose, its important that you get tested if you had unprotected sex with someone that could be infected. A chlamydia test is the only way to know for sure whether or not you have chlamydia.
Management Of Sex Partners
Sex partners should be referred for evaluation, testing, and presumptive treatment if they had sexual contact with the partner during the 60 days preceding the patients onset of symptoms or chlamydia diagnosis. Although the exposure intervals defining identification of sex partners at risk are based on limited data, the most recent sex partner should be evaluated and treated, even if the time of the last sexual contact was > 60 days before symptom onset or diagnosis.
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Getting Treated For Chlamydia And Often Gonorrhea
If you have your own doctor, he will prescribe the antibiotics you need to treat chlamydia. If you dont have your own doctor, you can often find free or low-cost care at either a Planned Parenthood site or a community health clinic.
Listen carefully to the instructions for taking the medicine that you are given by the doctor or other healthcare provider, and follow them closely.
Ask questions if you dont understand something. Also, if you have other questions as you take your medicine, you can always call the pharmacist for help. They are often easier to reach than the doctor.
If you test positive for chlamydia, your healthcare provider is likely to also recommend that you be treated for gonorrhea. This is because the cost of treating gonorrhea is less than the cost of testing for the infection.
Summary Of The Evidence
There is no evidence relating to patient values and preferences but the Guideline Development Group agreed that there is probably no variability in the values people place on the outcomes. Research related to other conditions indicates that adherence may be improved with simpler medication regimens. The GDG therefore agreed that azithromycin may be more acceptable to patients since it is a single dose regimen . There is little to no evidence for equity issues and feasibility. Resistance in other infections that often co-occur with chlamydia may restrict the use of some medicines, such as ofloxacin. For many of these medicines, costs may differ between countries in places with high incidence of chlamydia, the cost differences between azithromycin and doxycycline may be large due to greater numbers of people requiring treatment.
In summary, there was moderate quality evidence for trivial differences in benefits and harms between azithromycin and doxycycline, and although the cost of azithromycin is higher, the single dose may make it more convenient to use than doxycycline. While the differences are also trivial with the other medicines, the evidence is low quality and these are therefore provided as alternatives, with the exception of delayed-release doxycycline, which is currently expensive.
See for list of references of reviewed evidence, and for details of the evidence reviewed, including evidence profiles and evidence-to-decision frameworks .
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Doxycycline Resistance And C Trachomatis
Despite the absence of recent MIC data for C. trachomatis, low values of MICs of doxycycline were reported in the literature with MIC90 usually0.125 mg/L.,, Interestingly, doxycycline minimum chlamydiacidal concentrations varied according to the clinical presentation and the bacterial serovar, with lower MCCs in cases of asymptomatic infection than in mucopurulent cervicitis and pelvic inflammatory disease, and the highest MCCs observed for serovar Ia and J in mucopurulent cervicitis and pelvic inflammatory disease. In contrast, no MIC or MCC difference was observed between isolates recovered in the case of treatment failure or persistence compared with single-episode isolates. From these data and treatment success rates, pathogen resistance is expected to be low. However, tetracycline- and doxycycline-resistant isolates and isolates resistant to multiple antibiotics have been reported, some of thembut not allbeing involved in relapsing or persistent infection.
When Not To Take Doxycycline
You cannot take Doxycycline if you are allergic to doxycycline hyclate, or other similar antibiotics . When you fill in the short online medical questionnaire it is important to mention any health problems and medications that you are taking. If the duty GP cant prescribe Doxycycline, you may be offered Azithromycin instead. If you have any of the following medical conditions, your online Doctor will check whether Doxycycline is safe for you to use, and whether you need to take special precautions.
- Warfarin or other anticoagulants
- Penicillin or rifampicin
- Medicines such as antacids containing aluminium, calcium or magnesium or other medicines containing iron, bismuth or zinc salts. Do not take at the same time as Doxycycline capsules, as absorption of doxycycline may be reduced.
- Phenobarbital, carbamazepine, phenytoin or primidone
- Oral contraceptives
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How Long Can Chlamydia Stay In Your System
Chlamydia can lie dormant in the body for many years causing a low grade infection without symptoms. It could potentially flare up to cause a symptomatic infection, especially if there is an alteration in the persons immune system, such as a severe cold or flu, cancer or some other severe illness.
How Common Is It
Oral chlamydia is not as common as genital chlamydia. Research shows that approximately 10% of people who visited a sexually transmitted disease clinic had genital chlamydia, but only 1.5% also had an infection in the throat.
Genital gonorrhea is not as common as genital chlamydia, but oral gonorrhea is more common than oral chlamydia.
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How Does Doxycycline Work
When you take a seven to ten day course of twice daily Doxycycline tablets, the active ingredient in Doxycycline prevents the growth of chlamydia trachomatis bacteria in your urethra. If you take the tablets exactly as instructed by your online Doctor, the chlamydia infection will be cured and any symptoms will disappear. Studies have shown that Doxycycline may have a 100% success rate when used to treat chlamydia. Doctors consider it to be an effective first line treatment against the disease.
Use In Pregnancy And Breastfeeding
Doxycycline is labelled as Pregnancy Category D in the FDA classification. So, doxycycline should be avoided during pregnancy because of severe adverse effects including teratogenicity, permanent yellowish-brown teeth discoloration after in utero exposure and rare fatal hepatotoxicity, and is therefore contraindicated past the fifth week of pregnancy. However, despite this categorization as a class D agent, doxycycline was FDA approved for use in pregnant women following exposure to biothreat agents, including Bacillus anthracis, Yersinia pestis and Francisella tularensis.
Recently, a systematic review of doxycycline in pregnant women revealed a safety profile significantly different from that of tetracycline with no correlation between the use of doxycycline and teratogenic effects during pregnancy or dental staining in children.
Although doxycycline produces measurable milk levels, it is not contraindicated during the nursing period.
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What Is The Dosage Of Azithromycin For Chlamydia
The recommended dosage of azithromycin for chlamydia is 1 gram as a single dose. This dose may be taken morning or night and can be taken with or without food. Another name for azithromycin is Zithromax.
If you have taken your dose of azithromycin on an empty stomach and your stomach has become a bit upset or you feel sick, it is Ok to eat some food, which may help to settle it.
A 500mg dose of azithromycin is not recommended by guidelines to cure chlamydia. There is also a chance it may increase the risk of C. trachomatis bacteria becoming resistant to it. If you have only taken or only been prescribed a 500mg dose of azithromycin, you need to return to your doctor to get a 1 gram dose prescribed. You should never share your dose of azithromycin with another person.
What Are The Treatments For Chlamydia
If you are diagnosed with chlamydia, your doctor will prescribe oral antibiotics. A single dose of azithromycin or taking doxycycline twice daily for 7 to 14 days are the most common treatments and are the same for those with or without HIV.
With treatment, the infection should clear up in about a week. Do not have sex for at least 7 days until you have taken all of your medication, and do not stop taking the antibiotics even if you feel better.
Your doctor will also recommend that your partner be treated as well to prevent reinfection and further spread of the disease.
Women with serious infections, such as pelvic inflammatory disease, may require a longer course of antibiotics or hospitalization for intravenous antibiotics. Some severe pelvic infections may require surgery in addition to antibiotic therapy.
Make sure you get retested after three months to be certain the infection is gone. Do this even if your partner has been treated and appears to be infection free.
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Treatment For Chlamydia Is Quick And Easy
Two antibiotics are most often used for treating chlamydia:
- Azithromycin The main treatment for chlamydia is one gram of azithromycin, taken one time, says , deputy director of clinical services for public health with the Seattle and King County HIV and STD Program in Washington. That one gram comes as either two pills or four pills. It is not expensive.
- Doxycycline If your doctor prescribes doxycycline, you will take two pills daily for one week. It costs somewhat more than azithromycin.
Antibiotics can also cure chlamydia in infants, who can get the infection from their mothers, and treatment is essential for them. Without treatment, infants infected with chlamydia can develop conjunctivitis, which can cause blindness, or pneumonia, which can be fatal.
How Does Chlamydia Spread
Chlamydia is spread when a person has unprotected sex with an infected person.
Because chlamydial infection often has no symptoms, many people do not realise they have the infection.
Even if you know a person well, you may not be able to tell they have an STI, because people can look healthy and still have chlamydia.
Remember, you can get chlamydia and other STIs from a new sexual partner who has in the past had sex with someone who is infected.
It can also be spread from a long-term partner who has had sex with other people.
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Can You Drink Alcohol While Taking Azithromycin For Chlamydia
Yes, you may drink a small amount of alcohol while you are taking azithromycin but there is a chance large amounts of alcohol may increase the gastrointestinal side effects of azithromycin, such as nausea, diarrhea, vomiting, abdominal pain, dyspepsia, or flatulence. Too much alcohol with azithromycin may also give you a headache.
Because azithromycin is usually taken as a one-off dose, drinking alcohol is unlikely to stop azithromycin from curing chlamydia.
Doxycycline And Other Medicines
Please tell your doctor if you are taking or have recently taken any of the following medicines:
- Warfarin or warfarin-type anticoagulants .
- Quinapril .
- Kaolin .
- Penicillin or rifampicin .
- Sucralfate .
- Barbiturates .
- Ergotamine .
- Typhoid vaccine oral capsules.
- Carbamazepine, phenytoin, primidone, or other drugs used to control epilepsy.
- Ciclosporin .
- Methoxyflurane . If you need an operation, tell your doctor or dentist that you are taking doxycycline.
- Methotrexate .
- Medicines such as antacids containing aluminium, calcium, magnesium, or other medicines containing iron, bismuth, or zinc salts.
- Retinoid, e.g. Roaccutane .
- Lithium .
Doxycycline and the contraceptive pill
There is conflicting advice regarding doxycycline and the contraceptive pill. The patient leaflet advises doxycycline
may make the oral contraceptive pill less effective. You should use additional contraceptive precautions whilst taking this medicine and for 7 days after stopping. Whereas the NHS and FSRH advise additional contraceptive precautions are not necessary.
From NHS – Doxycycline:
Doxycycline does not affect any type of contraception, including the contraception pill and emergency contraception. However, if doxycycline makes you vomit or have severe diarrhoea for more than 24 hours, your combined pill may not protect you from pregnancy. Look on the pill packet to find out what to do.
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Can I Take Doxycycline And Drink Alcohol
Our online Doctors generally do not recommend drinking alcohol while you are taking any prescription medicine. Doxycycline is not compatible with alcohol and you should not drink at all while you are using this medication. If you feel that you cannot abstain from alcohol for the 7-10 days that it takes to treat chlamydia, you should tell your online Doctor.
How Is Chlamydia Treated
Since chlamydia is caused by a bacterial infection, treatment for chlamydia is a regimen of oral antibiotics. The most common recommended course of treatment for how to cure chlamydia is to prescribe Doxycycline or Azithromycin . The infection should clear after one to two weeks after taking the prescribed chlamydia pills.
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