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How To Treat Chlamydia Trachomatis

Ophthalmia Neonatorum Caused By C Trachomatis

Gonorrhea & Chlamydia Trachomatis â Infectious Diseases | Lecturio

A chlamydial etiology should be considered for all infants aged 30 days who experience conjunctivitis, especially if the mother has a history of chlamydial infection. These infants should receive evaluation and age-appropriate care and treatment.

Preventing Ophthalmia Neonatorum Caused by C. trachomatis

Neonatal ocular prophylaxis with erythromycin, the only agent available in the United States for this purpose, is ineffective against chlamydial ophthalmia neonatorum . As an alternative, prevention efforts should focus on prenatal screening for C. trachomatis, including

Neonates born to mothers for whom prenatal chlamydia screening has been confirmed and the results are negative are not at high risk for infection.

Diagnostic Considerations

Treatment

Erythromycin base or ethylsuccinate 50 mg/kg body weight/day orally, divided into 4 doses daily for 14 days*

* An association between oral erythromycin and azithromycin and infantile hypertrophic pyloric stenosis has been reported among infants aged < 6 weeks. Infants treated with either of these antimicrobials should be followed for IHPS signs and symptoms.

Although data regarding use of azithromycin for treating neonatal chlamydial infection are limited, available data demonstrate that a short therapy course might be effective . Topical antibiotic therapy alone is inadequate for treating ophthalmia neonatorum caused by chlamydia and is unnecessary when systemic treatment is administered.

Follow-Up

How Chlamydias Passed On

Chlamydia is usually passed from one person to another through sexual contact.

You can get the infection if you come into contact with the semen or vaginal fluids of someone who has chlamydia.

Chlamydia is most commonly spread through:

  • sharing sex toys that arent washed or covered with a new condom each time theyre used.

It can be spread by giving or receiving oral sex with someone who has chlamydia. The risk can be lowered by using a condom or a dam to cover the genitals.

If infected semen or vaginal fluid comes into contact with the eye it can cause conjunctivitis (infection or irritation of the eye.

If youre pregnant its possible to pass chlamydia to the baby .

Its not clear if chlamydia can be spread by transferring infected semen or vaginal fluid to another persons genitals on the fingers or through rubbing vulvas together.

You cant get chlamydia from kissing, hugging, sharing baths or towels, swimming pools, toilet seats or from sharing cups, plates or cutlery.

Causes And Risk Factors

Chlamydia is an STI caused by a specific strain of bacteria known as Chlamydia trachomatis.

Chlamydia is more common in women than in men. In fact, its estimated that the overall rate of infection is for women than men in the United States.

Some of the other risk factors for infection include:

  • not using barrier methods like condoms consistently with new sexual partners
  • having a sexual partner who is having sex with other people
  • having a history of chlamydia or other STIs

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What Happens If You Dont Seek Treatment

If you take your antibiotics as directed, chlamydia is likely to go away. But if its left untreated, it can cause a few complications.

For example, if you have a vulva, you could develop pelvic inflammatory disease . PID is a painful infection that could damage your uterus, cervix, and ovaries.

Untreated chlamydia can also lead to scarred fallopian tubes, which can cause infertility.

If youre pregnant, untreated chlamydia can be transmitted to the baby during vaginal delivery. Chlamydia can cause eye infections and pneumonia in newborns.

Untreated chlamydia can lead to epididymitis, which is when the epididymis becomes inflamed, causing pain.

Chlamydia can also spread to the prostate gland, which can lead to painful sex, lower back pain, and a fever.

Fortunately, treatment for chlamydia is relatively straightforward. And if its treated quickly, youre unlikely to experience any long-term complications.

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Chlamydia Is Common But Many People Dont Realize They Have It

Table 3 from Diagnosis and treatment of Chlamydia trachomatis infection ...

About 1.7 million chlamydia infections were reported to the Centers for Disease Control and Prevention in 2017, but the real number is likely higher because chlamydia is considered an underreported infection.

âThe number of reported cases is substantially lower than the true estimated incidence,â says Bradley Stoner, MD, PhD, associate professor of medicine at the Washington University School of Medicine in St. Louis and former president of the American Sexually Transmitted Diseases Association.

The National Notifiable Diseases Surveillance System relies on state and local public health departments to collect and report data on chlamydia to the CDC. Those public health departments depend on individual physicians, hospitals, and laboratories to report cases of chlamydia to them. Accurate statistics require all parties to routinely comply with disease-reporting mandates.

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How Is Chlamydia Diagnosed

The most common test for chlamydia is called a nucleic acid amplification test . Your provider takes a sample of fluid by doing a vaginal/cervical swab or collecting a urine sample. Then, they send the sample off to a lab to check for the bacteria that causes chlamydia. Your provider may do the test in an office, or they may ask you to do an at-home chlamydia test. Follow your providers instructions carefully to ensure you get accurate test results.

Because most chlamydia cases are asymptomatic, its important to get screened for chlamydia even if you dont notice any signs of infection. The CDC recommends that sexually active cisgender women who are high-risk for chlamydia get screened regularly. Women, more so than men, experience the most severe complications from chlamydia. Transgender men and nonbinary individuals with vaginas should be screened regularly, too, as they can experience the same complications of chlamydia.

Youre considered high-risk if you:

  • Are under 25.
  • Have had chlamydia infections previously.

Cisgender men, or trans and nonbinary individuals with penises, should be screened for chlamydia if:

  • They live in a setting where chlamydia spreads frequently, like correctional facilities, adolescent clinics and sexual health clinics.
  • They have sex with other men.

Yes You Can Get A Sexually Transmitted Infection Without Having Sex

Here are 12 ways you can pick up an STI without any of the fun that usually goes along with sex.

According to the Centers for Disease Control and Prevention, nearly 20 million new cases of reportable sexually transmitted infections occur each year in the U.S., almost half of them among young people between 15 and 24 years old. Reportable STIs include HIV, gonorrhea, Chlamydia, and syphilis.

The fact that these diseases are transmitted via sex doesnt mean its the only way you can get them. And just because you cant get HIV through things like mosquito bites and kissing, doesnt mean there arent other STIs you can. Here are 12 ways you can get an STI without having sex.

1. Mosquito bites. Zika the mosquito-borne disease that impacts fetal brain development has been shown to be sexually transmitted . Itscapable of great damage to fetuses, infants, and pregnant women but scientsts discovered its also killing brain cells in otherwise healthy adults. So slather on that insect repellant and make sure your partner does too!

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Barriers And Challenges To Diagnosis

The medical system does not fully meet the needs of some populations, including young people and men who have sex with men, regarding their sexual and reproductive health.

Ongoing barriers among young people include reluctance to use available health services, limited access to STI testing, worries about confidentiality, and the shame and stigma associated with STIs.

Men who have sex with men have a higher incidence of STIs than other groups. Since STIs are associated with a higher risk of human immunodeficiency virus infection, it is important to detect, diagnose, and manage STIs in this groupand in all high-risk groups. Rectal STIs are an independent risk factor for incident HIV infection. In addition, many men who have sex with men face challenges navigating the emotional, physical, and cognitive aspects of adolescence, a voyage further complicated by mental health issues, unprotected sexual encounters, and substance abuse in many, especially among minority youth. These same factors also impair their ability to access resources for preventing and treating HIV and other STIs.

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Symptoms Can Differ For Men And Women

Chlamydia: Morphology, Types, Pathogenesis, Diagnosis, Treatment

By and large, most cases of chlamydia are asymptomatic they are picked up by screening, which is why itâs so important to have good screening programs in place, notes Dr. Stoner. Men or women who have chlamydia symptoms may experience painful urination.

Women may also have these symptoms:

  • Smelly discharge from the cervix
  • Pain during sex

And men may have these symptoms:

  • Discharge from the penis

You can lower your risk of getting chlamydia and other STIs by:

  • not having sex with someone with chlamydia, even with a condom, until theyve finished treatment and 1 week has passed since their last dose of antibiotics
  • regularly getting tested for STIs, especially if you are under 30 and sexually active

Remember that most people with chlamydia dont show any symptoms and dont know they have it, so feeling âwellâ does not mean that you or your partner are not infected. If in doubt, get tested.

If you have chlamydia, you can help reduce the spread by letting your recent sexual partners know so they can get tested and treated.

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Female Complications Of Untreated Chlamydia

Some women develop PID, an infection that can damage the uterus, cervix, and ovaries. PID is a painful disease that often requires hospital treatment.

Infertility is also possible if chlamydia is left untreated because the fallopian tubes may become scarred.

During pregnancy, the infection can to babies during birth, which can cause eye infections and pneumonia in newborns.

Genotyping & Quantification Of Organism Load

Chlamydial fingerprinting will be conducted on specimens that are PCR positive at baseline and at test of cure. We will determine the organism load, identify the chlamydia serovar of each infection through a series of quantitative PCR assays to establish whether or not the genotype of the chlamydia detected in those women who have a repeat positive is the same as the type present at baseline . Initial qPCR primers and probes have been designed to predict antigenic differences in major outer membrane protein to determine the serovar as previously described . The primary chlamydia group-specific multiplex quantitative PCR will target conserved regions of the ompA gene specific to all chlamydia serovar groups, including the B group , C group or intermediate group serovars. This assay will enable quantification of organism load and will be used to direct serovar-specific PCRs to determine serovars present in the specimen, including possibility of mixed serovars .

Specimens from participants where the same serovar has been detected at baseline and follow up will undergo further discriminatory confirmation of relatedness using sequencing of ompA gene, as well as five house-keeping genes utilizing a multilocus sequence typing approach . This will include the amplification and sequencing followed by determining MLST type using C. trachomatis MLST database .

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How Long Does It Take For Chlamydia To Go Away After Treatment

Chlamydia normally goes away by the end of the course of antibiotics.

If you are experiencing symptoms, these can start to clear up very soon after starting your treatment. However, you need to finish the whole course to ensure that the infection has been completely treated.

If you are still experiencing symptoms at the end of your course of antibiotics, get medical advice as soon as possible. You may need to try a different type of antibiotic.

Know Your Sexual Health Status

How to recognize and treat Chlamydia trachomatis

If you have recently changed sexual partners, or have multiple sex partners, getting regularly tested for STIs will tell you if you have an infection. Some people can have an STI and not have any symptoms. Finding and treating an STI reduces the chances of passing infections on to your partner.

The more partners you have, the higher your chances of getting exposed to STIs.

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Can You Get Hiv From A Tattoo Or Body Piercing

Yes. There can be a risk for HIV or another blood-borne infection if the instruments used for piercing or tattooing either are not sterilized or disinfected between clients. Any instrument used to pierce or cut the skin should be used once and then disposed of safely. If youâre thinking to get tattooed or pierced, ask the staff to show you the precautions that they use. If youâve have any doubts about the cleanliness of their tools, go elsewhere.

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Chlamydia Is A Serious Infection

Chlamydia is Americas most common bacterial sexually transmitted infection. Every year, an estimated 2.86 million infections occur. Since its so common, you may assume that its no big deal. However, chlamydia can be a very serious infection.

Chlamydia is very common, but that doesnt mean it cant have a serious impact on your health. The infection can cause a number of long-term complications. In up to 15 percent of women with untreated chlamydia, the infection spreads to the uterus and uterine tubes, leading to symptomatic pelvic inflammatory disease. In addition, some women experience subclinical inflammation of the upper genital tract. This can cause permanent damage to the affected tissues.

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What Are The Symptoms Of Chlamydia

If you do notice symptoms, youll likely experience them differently based on your reproductive anatomy. Many of the symptoms that cisgender women experience can also affect transgender men and nonbinary individuals with vaginas. Many of the symptoms that cisgender men notice can affect transgender women and nonbinary individuals with penises, too.

Signs of chlamydia if you have a vagina

Chlamydia bacteria often cause symptoms that are similar to cervicitis or a urinary tract infection . You may notice:

  • White, yellow or gray discharge from your vagina that may be smelly.
  • Pus in your urine .
  • Increased need to pee.
  • Itching or burning in and around your vagina.
  • Dull pain in the lower part of your abdomen.

Signs of chlamydia if you have a penis

Chlamydia bacteria most often infect your urethra, causing symptoms that are similar to nongonococcal urethritis. You may notice:

  • Mucus-like or clear, watery discharge from your penis.
  • Pain or a burning sensation when you pee .

Signs of chlamydia that all genders may notice

Chlamydia can affect parts of your body other than your reproductive organs, such as your:

  • You may notice pain, discomfort, bleeding or a mucus-like discharge from your bottom.
  • Throat. You may have a sore throat, but you usually wont notice symptoms if the bacterias in your throat.
  • Eyes. You may notice symptoms of conjunctivitis if C. trachomatis bacteria gets in your eye. Symptoms include redness, pain and discharge.

Discharge From The Vagina

Ophthalmology 076 a Trachoma What is Chlamydial Trachomatis Conjunctivitis

In this chapter, we organize the different infections a woman can have by the symptoms the infection causes. Discharge from the vagina can be a symptom of chlamydia, gonorrhea, trichomonas, or a vaginal infection that is not sexually transmitted. Chlamydia and gonorrhea Chlamydia and gonorrhea are both serious illnesses. But they are easy to cure if they are treated early. If they are not treated, they can lead to severe infection or infertility in women and men. Both men and women can have chlamydia or gonorrhea with no signs. And even a person with no signs can pass chlamydia or gonorrhea to another person. If possible, every pregnant woman should be tested for chlamydia and gonorrhea. If the test shows she has one or both of these infections, she and her partner should be treated. But if it is not possible for her to be tested, and she or her partner have signs of the infection, they should be treated anyway. It is better to treat someone who might beâ¦

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New Approach Is Both Prevention And Treatment

Our treatment is the first combination therapy, a two-pronged approach, says the lead researcher, Emmanuel Ho, PhD, an associate professor in the school of pharmacy at the University of Waterloo.

The treatment makes use of nanoparticles to deliver treatment to infected cells. The dual approach prevents the majority of chlamydia bacteria from entering cells in the genital tract and then destroys any bacteria that is able to penetrate a cell wall.

In the laboratory, the gene therapy has successfully killed skin cells infected with chlamydia while at the same time protecting healthy cells. Currently, the only ways to prevent transmission of chlamydia are abstinence and the use of latex condoms. There is no vaccine available.

The first part of the therapy is preventive: It delivers a gene that reduces expression of the chlamydia protein on cells. This means that we will be able to prevent or reduce the chlamydia actually binding to cells that it affects, says Dr. Ho.

The second part is treatment that kicks in if the chlamydia is still able to infect the cells after the gene introduction. Were able to elicit a cellular response where cells form a bubble around the chlamydia and then kill it, says Ho.

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Treating Other Types Of Chlamydial Infections

Two other conditions caused by Chlamydia trachomatis are uncommon in the United States, but very common worldwide:

  • Lymphogranuloma venereum : Lymphogranuloma venereum is treated in the same way as standard genital chlamydia infections, but a longer course of therapy is used . Other care may also be required to treat genital ulcers or abscessed inguinal nodes if they occur.
  • Trachoma: Trachoma is the leading preventable cause of blindness worldwide and often requires aggressive treatment with antibiotics and surgery addressing unsanitary living conditions is also necessary.

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