Preparation Of Solid Dispersions
Solid dispersions of azithromycin were prepared in drug: carrier weight ratios as 1:1, 1:3, 1:5, 1:7 and 1:9, using the solvent evaporation method. 100 mg of azithromycin dihydrate was dissolved in 10 mL of 96% ethanol and the carrier was then added and dissolved at 40 °C, following continuous mixing on a hot plate to obtain a clear solution. Afterwards, the solvent was allowed to evaporate. The prepared solid dispersions were collected, sieved, and stored in desiccators until subsequent analysis. The process of evaporation was opted until a constant weight was obtained. Overall, the yield was approximately 98%.
Follow Treatment Advice Make Sure Chlamydia Is Properly Treated
However, the sexual partner may opt to be tested for chlamydia and wait for their results. If they do this, there should be no sexual activity while waiting to be tested, until their results are available, and then for the time period to complete treatment, if they test positive.
In many ways, including the fact no tests are 100% accurate, it is preferable for both of you to be treated, and the easiest option, is to take your antibiotics both at the same time. This is called epidemiological treatment, and is good medical practice.
If all the tablets were taken correctly and there has been no sex on treatment, there is no need to repeat the chlamydia test .
However a test of cure should be performed if:
- there is chlamydia in the rectum,
- it chlamydia is treated in pregnancy,
- it chlamydia is treated with erythromycin,
- if you have symptoms when diagnosed with chlamydia, and these symptoms have not resolved, or
- if any of the rules about taking treatment were not followed.
Does Azithromycin Cure Chlamydia
Cure rates of 97% were reported in an analysis of 12 randomized clinical trials that investigated the use of azithromycin 1 gram for the treatment of chlamydia. That means for every 100 people with chlamydia who take azithromycin, 97 will be cured and 3 will not be cured.
This relies on the person with chlamydia taking azithromycin exactly as directed and not sharing the medication with anyone. Any sexual partners must be also treated.
Although azithromycin cures chlamydia in most people, it will not repair any permanent damage done to tissues by the disease.
If you have been symptomatic with chlamydia before treatment and your symptoms continue for more than a few days after receiving treatment, then ask to be re-evaluated by your health care provider.
Unfortunately, repeat infection with chlamydia is common. This means that even though azithromycin has cured your current infection with chlamydia, this does not mean you will not get chlamydia again. If your sexual partners have not been appropriately treated, you are at high-risk for reinfection. Having chlamydia multiple times puts women at high risk of fertility problems, ectopic pregnancy, and pelvic inflammatory disease. Infants born to mothers who are infected with chlamydia may develop chlamydial conjunctivitis and/or pneumonia. Chlamydial infection in infants can be treated with antibiotics.
Also Check: How Bad Can Chlamydia Get
What Are The Treatments For Chlamydia
If you are diagnosed with chlamydia, your doctor will prescribe oral antibiotics. A single dose of azithromycin or taking doxycycline twice daily for 7 to 14 days are the most common treatments and are the same for those with or without HIV.
With treatment, the infection should clear up in about a week. Do not have sex for at least 7 days until you have taken all of your medication, and do not stop taking the antibiotics even if you feel better.
Your doctor will also recommend that your partner be treated as well to prevent reinfection and further spread of the disease.
Women with serious infections, such as pelvic inflammatory disease, may require a longer course of antibiotics or hospitalization for intravenous antibiotics. Some severe pelvic infections may require surgery in addition to antibiotic therapy.
Make sure you get retested after three months to be certain the infection is gone. Do this even if your partner has been treated and appears to be infection free.
Can I Drink Alcohol 3 Days After Taking Azithromycin
Azithromycin doesnt pose the same severe risk as other antibiotics when mixed with alcohol. Many people can drink moderately or begin drinking as soon as they finish their course of the medication. However, it is recommended that you wait three days before consuming alcohol after using an antibiotic.
Can You Crush azithromycin tablets and take them that way?
can i crush up the zithromax 500mg tablets and take them that way? Azithromycin crush: Yes the tablets can be crushed and mixed with water or food. As well it can be put through a feeding tube.
Can you take azithromycin through a feeding tube?
As well it can be put through a feeding tube. It does not taste the best, however! would mix it with something to mask the taste . Azithromycin: Cannot see why this should be a problem, but the best person to answer that would be your friendly pharmacist.
Don’t Miss: How Can You Treat Chlamydia At Home
What Is The Typical Z
Z-Packs are available as a package containing 6 tablets, 250 mg each. Youll start by taking 2 tablets on the first day as a single dose, followed by 1 tablet on days 2 through 5. For children, the dosing is typically based on their weight and what condition is being treated. Theres a similar product called the Tri-Pak that comes with 3 tablets of azithromycin, each containing 500 mg. With this product, you typically take one tablet daily for 3 days.
Its important to take your Z-pack as prescribed. Try to take it at the same time every day youre supposed to take it until you finish the entire prescription regimen. Not completing your treatment can increase the risk that your infection returns and that the bacteria start becoming insensitive to azithromycin, known as antibiotic resistance. This makes the bacteria more difficult to treat.
You May Like: How Long Can You Have Chlamydia And Not Know
What Is Azitromicina 500mg Used For
Apo-Azithromycin tablets 500mg contain azithromycin , a macrolide antibiotic used to treat a variety of bacterial infections including respiratory, skin, sexually transmitted , and ear/eye infections also to prevent opportunistic infection people with HIV.
What is azithromycin tab?
Azithromycin tablets are a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below.
Don’t Miss: How Long Does It Take To Detect Chlamydia
Male Issues Of Untreated Chlamydia
Male can likewise experience complications when chlamydia is left neglected. The epididymis television that holds the testicles in place might become irritated, causing discomfort. This is known as epididymitis.
The infection can additionally spread to the prostate gland, triggering a high temperature, unpleasant sexual intercourse, as well as discomfort in the reduced back. One more feasible issue is male chlamydial urethritis.
These are simply some of the most common difficulties of without treatment chlamydia, which is why it is necessary to obtain medical attention as soon as possible. The majority of people that obtain therapy rapidly have no lasting medical problems. Can You Get Rid Of Chlamydia Naturally
Link to next post: Can You Give Chlamydia Through Oral
Hi there, Im Melissa and welcome to Genier. Im not ashamed to admit that Ive dealt with an STD before and recovered. It was not a pleasant experience but Im glad I got myself tested. If theres one message that you can take away from my site is get tested today! Stay safe.
Read Also: Womens Symptoms Of Gonorrhea And Chlamydia
Interactions With Other Medicines And Other Forms Of Interactions
Azithromycin does not interact significantly with the hepatic cytochrome P450 system. It is not believed to undergo the pharmacokinetic drug interactions as seen with erythromycin and other macrolides. Hepatic cytochrome P450 induction or inactivation via cytochrome-metabolite complex does not occur with azithromycin.
Also Check: Can Chlamydia Naturally Go Away
How Do I Know If I Have Chlamydia
If you suspect you have chlamydia, your doctor may want to test cervical or penile discharge or urine using one of several available methods.
In most cases of chlamydia, the cure rate is 95%. However, because many women donât know they have the disease until it has caused serious complications such as pelvic inflammatory disease, sexually active women under age 25 and others at higher risk should be tested for chlamydia once a year during their annual pelvic exam even if they dont have symptoms.
Pregnant women should also be tested as part of their routine lab work.
Is There A Liquid Form Of Azithromycin
Yes: but a liquid form is already available. Indeed, the majority of doses of it in the pediatric population is as a powder you mix up with water (keep in Read More
Can you take Advil with Zithromax?
Advil can be taken with zithromax without any worries. What i would like to tell you is that advil is very safe drug and can be used with many ofthe drugs without any noticeable drug reaction.
Can azithromycin tablets be crushed?
Azithromycin crush: Yes the tablets can be crushed and mixed with water or food. As well it can be put through a feeding tube. It does not taste the best, however! would mix it with something to mask the taste .
You May Like: How To Get Antibiotics For Chlamydia
How To Take Metronidazole
Use Metronidazole exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Metronidazole oral is taken by mouth.
Metronidazole injection is given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth.
Shake the oral suspension . Measure a dose with the supplied measuring device .
Swallow the extended-release tablet whole and do not crush, chew, or break it.
If you are treating a vaginal infection, your sexual partner may also need to take metronidazole so you don’t become reinfected.
Metronidazole is usually given for up to 10 days in a row. You may need to repeat this dosage several weeks later.
Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Metronidazole will not treat a viral infection .
Metronidazole will not treat a vaginal yeast infection. You may even develop a new vaginal yeast infection, which may need to be treated with antifungal medication. Tell your doctor if you have symptoms such as itching or discharge during or after treatment with metronidazole.
Do not share this medicine with another person, even if they have the same symptoms you have.
What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture . Keep liquid medicine in the refrigerator, tightly closed, and dispose of any unused medication after 10 days.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDAs Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Recommended Reading: What Antibiotics Do They Give You For Chlamydia
Why Is This Medication Prescribed
Erythromycin is used to treat certain infections caused by bacteria, such as infections of the respiratory tract, including bronchitis, pneumonia, Legionnaires’ disease , and pertussis diphtheria sexually transmitted diseases , including syphilis and ear, intestine, gynecological, urinary tract, and skin infections. It also is used to prevent recurrent rheumatic fever. Erythromycin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria.
Antibiotics such as erythromycin will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
When You Must Not Take It
You must not take AZITHROMYCIN MYLAN if you have an allergy to:
- Any medicine containing Azithromycin
- Any other ketolide or macrolide antibiotics
- Any of the ingredients listed at the end of this leaflet.
If you are not sure if you are allergic to any of the above, ask your doctor.
Symptoms of an allergic reaction may include:
- Shortness of breath
- Swelling of the face, lips, tongue or other parts of the body
- Skin rash, itching or hives.
You must not take AZITHROMYCIN MYLAN after the expiry date or use by date printed on the pack has passed or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should be given this medicine, talk to your doctor.
Don’t Miss: How To Get Chlamydia Treatment For Your Partner
What Happens If Chlamydia Goes Untreated
Chlamydia often has no symptoms therefore, some people go untreated. Even with those who have symptoms stigma, access, or other reasons get in the way of getting medical attention. Not receiving prompt and proper treatment can create serious health problems. Chlamydia that goes untreated can increase the likelihood of contracting another STD, like gonorrhea or HIV/AIDS, or increasing the likelihood of transmitting that STD to someone else. It is also possible to develop reactive arthritis, or arthritis caused by the bodys reaction to an infection, because of chlamydia. This can affect the joints, urethra, and eyes.
For women, chlamydia that goes untreated can spread through your uterus to your fallopian tubes. Fallopian tubes connect the ovaries to the uterus and transport fertilized eggs during pregnancy. If untreated chlamydia spreads to this area, the result is pelvic inflammatory disease , affecting around 5% of women in the US.
Pelvic inflammatory disease, similar to chlamydia, can have no symptoms or just some pelvic or abdominal pain initially. Unfortunately, PID can do permanent damage to a womens reproductive system, including:
What Drugs And Food Should I Avoid While Taking Metronidazole
While taking metronidazole and for 3 days after your last dose: Do not drink alcohol or consume foods, medicines, or other products that contain alcohol or propylene glycol. You may have unpleasant effects such as headaches, nausea, vomiting, stomach cramps, and warmth or tingling under your skin.
Recommended Reading: Do Antibiotics Get Rid Of Chlamydia
Can You Get Chlamydia More Than Once
Yes, you can get the infection even if youve successfully treated it already.
A sexual partner who has chlamydia can transmit it to you again, even if youve already had it and treated it.
You can also get chlamydia again if it wasnt fully treated the first time. This can happen if you stop taking the necessary treatment. Its important to complete the antibiotics youve been given, even if your symptoms get better.
The CDC recommends getting tested 3 months after treatment of your initial infection to ensure the infection is cleared.
Drug Treatment Of Common Stds: Part Ii Vaginal Infections Pelvic Inflammatory Disease And Genital Warts
CAROL WOODWARD, PHARM.D., West Virginia University Hospitals, Morgantown, West Virginia West Virginia
MELANIE A. FISHER, M.D., M.SC., University, Morgantown, West Virginia
Am Fam Physician. 1999 Oct 15 60:1716-1722.
This is Part II of a two-part article on drug treatment of sexually transmitted diseases. Part I, Herpes, Syphilis, Urethritis, Chlamydia and Gonorrhea, appeared in the October 1 issue .
This article focuses on vaginal infections, pelvic inflammatory disease and genital warts, with brief mention of proctitis, enteritis and ectoparasitic infections. It should be noted that vaginal candidiasis and bacterial vaginosis are included in the following discussion, although these infections are not sexually transmitted. They are frequently diagnosed at the same time as sexually transmitted diseases , however, and the treatments often overlap.
Don’t Miss: What Cures Gonorrhea And Chlamydia
How Is Chlamydia Treated During Pregnancy
Because Doxycycline and Ofloxacin are not suitable for use in pregnancy, expectant mothers requiring chlamydia treatment will be given an alternative.
NICE recommends that prescribers consider one of the following in such cases:
- a three day course of Azithromycin
- or a seven day course of Erythromycin
- or a 14-day course of Erythromycin
- or a seven day course of Amoxicillin
Of course every case is different, and dependent on a patients medical profile.
Analysis Of Azithromycin Dihydrate
Azithromycin was analyzed at 215 nm using a UV spectrophotometer. The standard curve for the determination of drug was constructed by dissolving it in phosphate buffer pH = 6.0, in concentration range of 2 to 30 g/mL. In this concentration range, good linearity was observed . The graph obeyed the Beer-Lambert’s law in the selected concentration range.
Also Check: How Long Does Chlamydia Last Without Treatment